Prevalence of the BRCA1 founder mutation c.5266dupin Brazilian individuals at-risk for the hereditary breast and ovarian cancer syndrome
Abstract About 5-10% of breast and ovarian carcinomas are hereditary and most of these result from germline mutations in the BRCA1 and BRCA2 genes.In women of Ashkenazi Jewish ascendance, up to 30% of breast and ovarian carcinomas may Harnesses be attributable to mutations in these genes, where 3 founder mutations, c.68_69del (185delAG) and c.5266d